Process of making an internal remedy.



UNITED STATES PATENT OFFICE.

PROCESS OF MAKING AN INTERNAL REMEDY.

Specification of Letters Patent.

Patented June 26, 1906.

- Application filed May 25,1905. Serial No. 262,253-

To all whom it may concern;

Be it known that I, RICHARD GRIEsE, chemist, a subject of the King ofPrussia, German Emperor, residing at Berlin, Kingdom of Prussia, in theEmpire of Germany, have invented a new and useful Process of Making anInternal Remedy, of which the following is a specification.

The subject-matter of the present invention relates to a process forpreparing in a condition which renders possible its internal applicationthe complicated organic iodin compound metaiodinorthooxyquinolinsulfonic acid, (O ILIOHSO HNQ covered by the United States'Patent No. 576,494.

The present invention also relates to medicaments or internaldisinfectants containing this compound.

Hitherto the said organic iodin compound has been utilized in medicineonly for external treatment, the internal treatment having been hithertodeemed out of the question on account of the damage to the stomachconnected with such an internal application and on account ofdisturbances produced in the circulation of the blood. In order torender possible the internal application of the said iodin compound,which is very useful in itself, it is first and foremost necessary tobring the same into a readily-soluble condition, so that the compound onbeing taken is readily incorporated in the gastric juices or the blood.With this object in view a quantity of sodium bicarbonate, oleum menthaepiperitae, (peppermint-0H,) and, if desired, tannalbin (which consistsof tannic acid and albumin) are added in certain proportions. Thequantity of metaiodinorthooxyquinolinsulfonic acid, according to theexigencies of the case to be treated, varies between nine hundred andtwenty-five and four hundred grams per one thousand grams of themixture, and the amount of sodium bicarbonate between seventy-five andsix hundred grams, whereas the oleum menthae piperitae is added only bydrops, and when needed tannalbin is added to the extent of twenty-fivegrams per one thousand grams of the mixture.

The sodium bicarbonate is mixed with the peppermint-oil until the wholequantity of the said sodium compound mixes uniformly with the oil, whichhas been added in drops, or until the latter has dissolved in the formersubstance. To this sodium bicarbonate containing peppermint-oil themetaiodinorthooxyquinolin-sulfonic acid is then added andthoroughlyincorporatedtherewith,preferably by stirring and sifting. Themixture thus resulting, which is in the form of powder, is most suitablyintroduced into the wellknown capsules, which readily dissolve in themouth.

The compounding of the product is de pendent, according to therequirements to be determined in each case by the physician, not onlyupon variations within the above-stated limits, but also under somecircumstances several constituents appear to be dispensable-for example,the addition of tannalbin in all cases where the patient is not inclinedto diarrhea.

Experiment has shown that the addition of sodium bicarbonate effects thedesired easy solubility of the metaiodinorthoxyquinolin-sulfonic acid inthe gastric juice, improves the appetite during use, and in particularcauses animprovement in the progress of digestion, which has abeneficial effect on the general state of health of the patient.

The powder produced according to the process described has proved itselfto be a medimecant or internal disinfectant free from the unpleasanttaste of metaiodinorthooxyquinolin-sulfonic acid and the frequentlyloosening effect on the bowels of that iodin compound, which in itselfremains undissolved in the stomach, is opposed by a kind of bindinaction, in consequence of the tannalbin. s the said powder is alsoreadily soluble in water, in case of need it can be employed also forinjections under the skin, in which case it exercises a more violentbacteria-killing action.

What I claim as my invention, and desire to secure by Letters Patent, is

The herein-described process of producing from metaiodinorthooxyquinolinsulfonic acid an internal remedy capable of being assimilated andcarried into the blood circulation which consists in mixing bicarbonateof soda with a small proportion of oil of peppermint, and incorporatingsaid mixture with metaiodinorthooxyquinolin-sulfonic acid.

In testimony whereof I have signed my name to this specification inthe-presence of two subscribing witnesses.

RICHARD GRIESE.

Witnesses:

WOLDEMAR HAUPT, HENRY HASPER.

